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Dose reduction of rifabutin to half the standard dose and a dose increase of indinavir sulfate to 1000 mg every 8 hours are recommended when rifabutin and indinavir sulfate are coadministered.

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One study of about 500 early postmenopausal women has been conducted to date in which treatment with actonel 5 mg daily plus estrogen replacement therapy was compared to estrogen replacement therapy alone.