Patients must not take sulfa antibiotics, such as co-trimoxazole septra or trimethoprim, while taking methotrexate.
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therefore, you should be monitored carefully if you are receiving penicillin while being treated with methotrexate.
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the increased risk of liver damage with methotrexate is significant for people who drink alcohol.
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Therefore, if you are pregnant or your sexual partner is pregnant, or plans to become pregnant, do not take methotrexate.
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