For people with intolerance to both aspirin and modified-release dipyridamole, only clopidogrel is available for long-term prevention.
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aspirin and extended release dipyridamole capsules and other medicines may affect each other causing side effects.
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the study results suggested that aspirin 25 mg plus dipyridamole 200 mg, taken twice daily for the secondary prevention of ischaemic stroke, could be recommended as a cost-effective strategy for the management of patients who had already experienced ischaemic stroke.
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however, the committee was aware that the manufacturer of modified-release dipyridamole had commented that at a cost-effectiveness threshold of 20,000 per qaly gained, if the price of generic clopidogrel was about 50 of that of branded clopidogrel, modified-release dipyridamole plus aspirin would no longer be cost effective compared with clopidogrel.
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aspirin and dipyridamole were coded within a single variable 0, control; 1, aspirin; 2, dipyridamole; 3, dual therapy in each model.
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