Vasotec maleate has been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine and prazosin without evidence of clinically significant adverse interactions.
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it happens most commonly if the person is already taking another blood pressure-lowering medication, has just started treatment with prazosin, or starts treatment with prazosin at a higher dose.
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In newly diagnosed hypertensive patients, prazosin is particularly effective when used in combination with a thiazide diuretic polythiazide 2 to 4mg daily has been used in studies to date .
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