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contrarily, local application of estrogen has been shown to block the ability of fluvoxamine to slow serotonin clearance, suggesting that the same pathways which are involved in ssri efficacy may also be affected by components of local estrogen signaling pathways.
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changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment.
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tryptophan may enhance the serotonergic effects of fluvoxamine, and the combination should, therefore, be used with caution.
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