Generally, patients with a history of clozapine-associated myocarditis or cardiomyopathy should not be rechallenged with clozaril.
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the mechanism by which clozaril causes neutropenia is unknown and is not dose-dependent.
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, flu-like illness; fever; lethargy; general weakness or malaise; mucus membrane ulceration; skin, pharyngeal, vaginal, urinary, or pulmonary infection; or extreme weakness or lethargy occurring at any time during clozaril therapy, to aid in evaluation for neutropenia and to institute prompt and appropriate management.
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