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Pharmacokinetic modeling and simulation indicates that a dose of 200 mg daily in patients with severe renal impairment and a dose of 200 mg daily alternating with 400 mg the following day in patients with moderate renal impairment will provide plasma ribavirin exposures similar to that observed in patients with normal renal function receiving the standard 1000 1200 mg copegus daily dose.

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in study nv15942, all patients received pegasys 180 mcg subcutaneous once weekly and were randomized to treatment for either 24 or 48 weeks and to a copegus dose of either 800 mg or 1000 mg 1200 mg for body weight less than 75 kg greater than or equal to 75 kg .

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