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Patients who use lithium, monoamine oxidase inhibitors, tricyclics, and clozepine have serious drugdrug interactions, with increased physical risks, including withdrawal, and therefore qualify for american society of anesthesiologists asa ; classification 3.

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There have been a few reports of cardiac arrhythmias and or circulatory collapse and or cardiac arrest associated with the rapid intravenous administration of large doses of methylprednisolone greater than 500 mg administered over a period of less than 10 minutes .