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There have been a few reports of cardiac arrhythmias and or circulatory collapse and or cardiac arrest associated with the rapid intravenous administration of large doses of methylprednisolone greater than 500 mg administered over a period of less than 10 minutes .

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For the treatment of acute maxillary sinusitis infection the recommended dose is biaxin 500mg twice daily for 2 weeks or 2 biaxin xl tablets at a time once daily for 14 days.