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Pharmacokinetic modeling and simulation indicates that a dose of 200 mg daily in patients with severe renal impairment and a dose of 200 mg daily alternating with 400 mg the following day in patients with moderate renal impairment will provide plasma ribavirin exposures similar to that observed in patients with […]

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Switching dosage forms the conversion ratio for immediate release metoprolol tartrate and extended release metoprolol succinate is 1 1, therefore the same total daily dose of metoprolol should be used when switching formulations.