During the dosage titration period, serum calcium levels should be obtained at least twice weekly and, if hypercalcemia is noted, rocaltrol calcitriol should be immediately discontinued until normocalcemia ensues see precautions general .
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since rocaltrol is believed to be the active hormone which exerts vitamin d activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin d intake, ie, hypercalcemia syndrome or calcium intoxication depending on the severity and duration of hypercalcemia see warnings .
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some reports have shown that the concomitant administration of thiazides with rocaltrol calcitriol causes hypercalcemia.
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