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In many countries, the use of chloroquine persisted for a longer period of time before artemisinin-based combination therapy was introduced, and also where the acquisition of anti-malarial drugs from the private sector is common.

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many countries have observed decreases in the prevalence of chloroquine resistance with the discontinuation of chloroquine use.

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eye problems were much more common in the past when chloroquine was the most commonly used anti-malarial drug and dosages of these drugs were considerably higher.

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the return of chloroquine-susceptible malaria in malawi occurred via an expansion of susceptible parasites that had survived in the population despite chloroquine drug pressure 28 .
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Chloroquine is also active against other types of protozoa, including one called entamoeba histolytica which causes amoebic dysentry .

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