In one case, this occurred after an initial propranolol dose of 5 mg.
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chlorpromazine major propranolol appears to inhibit the hepatic metabolism of phenothiazine neuroleptics, and the phenothiazines appear to decrease the hepatic metabolism of propranolol.
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propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action.
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rifampin decrease the plasma levels of propranolol resulting in a loss of efficacy see clinical pharmacology .
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d-propranolol blocks the conversion of t4 to t3, but the therapeutic effect of this action is minimal.
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intrauterine growth retardation, small placentas, and congenital anomalies have been reported for neonates whose mothers received propranolol hcl during pregnancy.
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